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May 21, 2026Nucleic Acids ResearchOpen Access

Diverse stresses differentially regulate rRNA biogenesis and mRNA translation

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Authors

AAAnne AldrichRTRachael ThomasMBMichael Blower

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Overview

Randomized trial reveals that various stresses impact rRNA maturation and ribosome assembly, indicating new regulatory mechanisms.

Key Points

  • The study aims to uncover the regulatory mechanisms of ribosome biogenesis under differing stress conditions, particularly focusing on rRNA processing.
  • Defined novel regulatory mechanisms of ribosome biogenesis under stress conditions.
  • Examined the effects of heavy metals on pre-rRNA processing in human cells.
  • Analyzed the impact of endoplasmic reticulum stress on ribosomal protein synthesis and rRNA transcription.
  • Heavy metal-induced stress significantly affects early pre-rRNA processing.
  • 3' end processing of pre-rRNA occurs independently from 5' end processing in cells.
  • Endoplasmic reticulum stress disrupts the balance between ribosomal protein synthesis and rRNA transcription without inhibiting rRNA transcription.

Cite This Study

Aldrich et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea13abe05d6e3efb5fbc7https://doi.org/10.1093/nar/gkag499
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metal stress uncouples early pre-rRNA processing from ISR activation and reveals flexible checkpoints in human ribosome biogenesis2025
  2. 2Development, validation, and application of the ribosome separation and reconstitution system for protein translation in vitro2021 · 1 citations
  3. 3A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance2022 · 36 citations
  4. 4Nanopore Sequencing Reveals rRNA Modification Changes in Human Cells Experiencing Oxidative or Inflammatory Stress2026 · 1 citations
  5. 5Context specific ubiquitin modification of ribosomes regulates translation under oxidative stress2024 · 3 citations