⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 15, 2025

Extended Data Figure 1 from Fes-Deficient Macrophages Prime CD8⁺ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Brian J. Laight Danielle Harper Natasha Dmytryk Connie S. Zhang Changnian Shi Andrew Garven Richard W. Nauman Jacob Kment Faizah Alotaibi Іван Шаповалов Victoria Hoskin Yan Gao Jeffrey Mewburn Caitlyn Vlasschaert Ami Wang Julian Simonetti David P. LeBrun Kathrin Tyryshkin David M. Berman Amber L. Simpson Charles H. Graham Andrew W. Craig Sameh Basta Madhuri Koti Peter A. Greer

View at Publisher

Ask AI

Bookmark

Share

Key Points

Fes deficiency in macrophages leads to enhanced cd8 t cell priming and antitumor responses.
Lower fes expression correlates with reduced tumor growth rates and better survival outcomes.
The findings suggest a mechanistic role for fes in modulating macrophage function in tumor immunity.
This research highlights the potential for targeting fes in enhancing the efficacy of immunotherapy.

Implication

Macrophages with reduced fes expression prime cd8 t cells, improving tumor immunity and therapeutic responses.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Laight et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6e5 https://doi.org/10.1158/0008-5472.29568170

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extended Data Figure 7 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
2Extended Data Figure 5 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
3Extended Data Figure 3 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
4Extended Data Figure 9 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
5Extended Data Figure 6 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025

More related papers

Extended Data Figure 8 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 4 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Data from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025