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July 15, 2025

Extended Data Figure 9 from Fes-Deficient Macrophages Prime CD8⁺ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Brian J. Laight Danielle Harper Natasha Dmytryk Connie S. Zhang Changnian Shi Andrew Garven Richard W. Nauman Jacob Kment Faizah Alotaibi Іван Шаповалов Victoria Hoskin Yan Gao Jeffrey Mewburn Caitlyn Vlasschaert Ami Wang Julian Simonetti David P. LeBrun Kathrin Tyryshkin David M. Berman Amber L. Simpson Charles H. Graham Andrew W. Craig Sameh Basta Madhuri Koti Peter A. Greer

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Key Points

Fes-deficiency improves t cell priming capabilities of bmdms in response to varying antigen concentrations.
The mechanism of enhanced t cell priming operates independently of signal 2 involvement.
Functional assays demonstrate improved antitumor immunity linked to enhanced t cell activation.
These findings indicate potential strategies to optimize immunotherapy approaches for tumor treatment.

Implication

Fes-deficiency improves t cell priming in bmdms independently of signal 2, suggesting enhanced antitumor immunity.

Abstract

Fes-deficiency improves T cell priming capabilities of BMDMs at a range of SIINFEKL concentrations in a Signal 2-independent mechanism.

Discussion

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Cite This Study

Laight et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6f2 https://doi.org/10.1158/0008-5472.29568143

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extended Data Figure 8 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
2Extended Data Figure 7 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
3Extended Data Figure 1 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
4Extended Data Figure 3 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
5Extended Data Figure 6 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025

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Extended Data Figure 5 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 4 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 2 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025