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July 15, 2025

Extended Data Figure 2 from Fes-Deficient Macrophages Prime CD8⁺ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Brian J. Laight Danielle Harper Natasha Dmytryk Connie S. Zhang Changnian Shi Andrew Garven Richard W. Nauman Jacob Kment Faizah Alotaibi Іван Шаповалов Victoria Hoskin Yan Gao Jeffrey Mewburn Caitlyn Vlasschaert Ami Wang Julian Simonetti David P. LeBrun Kathrin Tyryshkin David M. Berman Amber L. Simpson Charles H. Graham Andrew W. Craig Sameh Basta Madhuri Koti Peter A. Greer

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Key Points

The study highlights how fes-deficient macrophages enhance CD8+ T cell activation, promoting antitumor immunity.
Experimental evidence shows improved antitumor immunity linked to enhanced CD8+ T cell priming by macrophages.
Methods included immunohistochemistry and immunoblot staining to analyze murine mammary glands.
Findings suggest that manipulating macrophage function could optimize immunotherapy strategies in cancer treatment.

Implication

IHC and immunoblot staining reveal that fes-deficient macrophages prime CD8+ T cells, suggesting improved antitumor responses in immunotherapy.

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Cite This Study

Laight et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6f0 https://doi.org/10.1158/0008-5472.29568167

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extended Data Figure 4 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
2Extended Data Figure 8 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
3Extended Data Figure 5 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
4Extended Data Figure 1 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
5Extended Data Figure 9 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025

More related papers

Extended Data Figure 7 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 6 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 3 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025