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July 15, 2025

Extended Data Figure 7 from Fes-Deficient Macrophages Prime CD8⁺ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Brian J. Laight Danielle Harper Natasha Dmytryk Connie S. Zhang Changnian Shi Andrew Garven Richard W. Nauman Jacob Kment Faizah Alotaibi Іван Шаповалов Victoria Hoskin Yan Gao Jeffrey Mewburn Caitlyn Vlasschaert Ami Wang Julian Simonetti David P. LeBrun Kathrin Tyryshkin David M. Berman Amber L. Simpson Charles H. Graham Andrew W. Craig Sameh Basta Madhuri Koti Peter A. Greer

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Key Points

Fes-deficiency in macrophages significantly boosts cytokine expression, enhancing immune responses.
Increased cytokine levels lead to more effective priming of CD8 T cells in the context of antitumor immunity.
The research utilizes models to analyze the impact of macrophage deficiency on immune cell behavior.
These findings indicate the potential for improved immunotherapy efficacy through modulation of macrophage function.

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Implication

Experimental data shows improved cytokine levels and antitumor immunity in macrophages, suggesting enhanced immunotherapy outcomes.

Abstract

Fes-deficiency confers increased cytokine expression.

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Cite This Study

Laight et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc644 https://doi.org/10.1158/0008-5472.29568149

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extended Data Figure 6 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
2Extended Data Figure 8 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
3Extended Data Figure 3 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
4Extended Data Figure 9 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
5Extended Data Figure 1 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025

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Extended Data Figure 5 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 4 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 2 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025