⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 15, 2025

Extended Data Figure 8 from Fes-Deficient Macrophages Prime CD8⁺ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Brian J. Laight Danielle Harper Natasha Dmytryk Connie S. Zhang Changnian Shi Andrew Garven Richard W. Nauman Jacob Kment Faizah Alotaibi Іван Шаповалов Victoria Hoskin Yan Gao Jeffrey Mewburn Caitlyn Vlasschaert Ami Wang Julian Simonetti David P. LeBrun Kathrin Tyryshkin David M. Berman Amber L. Simpson Charles H. Graham Andrew W. Craig Sameh Basta Madhuri Koti Peter A. Greer

View at Publisher

Ask AI

Bookmark

Share

Key Points

Fes-deficient macrophages stimulate CD8 T cells to enhance antitumor immunity.
Cytokine expression levels in Fes-deficient cells change over time, indicating adaptative responses.
The research investigates the role of macrophages in improving immunotherapy outcomes against tumors.
This work proposes new strategies for optimizing cancer treatments through the modulation of immune cells.

Implication

Fes-deficient macrophages prime CD8 T cells, improving antitumor immunity and immunotherapy effectiveness.

Abstract

Fes-deficient BMDMs show time-dependent changes in cytokine expression and localization.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Laight et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6e8 https://doi.org/10.1158/0008-5472.29568146

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extended Data Figure 7 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
2Extended Data Figure 9 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
3Extended Data Figure 3 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
4Extended Data Figure 5 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
5Extended Data Figure 1 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025

More related papers

Extended Data Figure 6 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 4 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025
Extended Data Figure 2 from Fes-Deficient Macrophages Prime CD8<sup>+</sup> T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy2025