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July 15, 2025

Supplementary Figure 4 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

Andrew E. Evans Sahida Afroz Alexa Magstadt Anup Kasi Dan A. Dixon

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Key Points

XPO1 inhibitor eltanexor modulates the Wnt/beta-catenin signaling pathway in colorectal cancer.
Study shows eltanexor does not change beta-catenin protein expression levels in treated cells.
Figure S4 illustrates that eltanexor does not affect intracellular localization of beta-catenin.
Findings suggest potential therapeutic implications of eltanexor without altering key signaling components of tumorigenesis.

Implication

Analysis reveals eltanexor affects tumorigenesis in colorectal cancer, without altering beta-catenin expression or localization.

Abstract

Figure S4. Eltanexor does not changes β-catenin protein expression or intracellular localization.

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Cite This Study

Evans et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc719 https://doi.org/10.1158/2767-9764.29568701

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
2Supplementary Figure 3 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
3Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
4Supplementary Figure 1 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
5Figure 2 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025

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Figure 3 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
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Figure 1 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025