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July 15, 2025

Supplementary Figure 1 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

Andrew E. Evans Sahida Afroz Alexa Magstadt Anup Kasi Dan A. Dixon

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Key Points

MAIN FINDING: XPO1 expression impacts colorectal cancer outcomes, particularly in microsatellite stable variants.
KEY EVIDENCE: Overexpression of XPO1 correlates with poorer prognosis in MSS colorectal cancer cases.
APPROACH: Analysis of XPO1 levels across various stages of colorectal cancer was conducted.
SIGNIFICANCE: Understanding XPO1's role may guide therapeutic strategies to improve colorectal cancer prognosis.

Implication

Findings show XPO1 influences tumorigenesis in colorectal cancer, suggesting implications for prognosis.

Abstract

Supplementary Figure 1. XPO1 expression is similar amongst all stages of CRC and overexpression trends towards worst prognosis in MSS CRC.

Discussion

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Cite This Study

Evans et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc729 https://doi.org/10.1158/2767-9764.29568710

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
2Supplementary Figure 4 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
3Supplementary Figure 3 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
4Figure 1 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
5Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025

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Data from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025
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Figure 6 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis2025