Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

Andrew E. Evans; Sahida Afroz; Alexa Magstadt; Anup Kasi; Dan A. Dixon

doi:10.1158/2767-9764.29568695

July 15, 2025

Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

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Key Points

Eltanexor effectively modulates the wnt/β-catenin signaling pathway, influencing colorectal cancer progression.
The treatment was well-tolerated in the experimental model using apcmin/+ mice, showing minimal adverse effects.
This research utilized a comprehensive analysis of tumorigenesis focusing on the effects of xpo1 inhibition.
Findings suggest eltanexor could be a promising candidate for therapeutic strategies against colorectal cancer.],
simple_explanation
Eltanexor is a treatment that helps reduce the growth of colorectal cancer by affecting a key pathway known as Wnt/β-catenin. Tests in special mice showed that this treatment is safe and works well. This is important because it means new therapies may be possible for people with this type of cancer. 🌟
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Implication

Eltanexor shows potential to reduce tumorigenesis by affecting the Wnt/β-catenin signaling pathway in colorectal cancer, indicating its therapeutic relevance.

Abstract

Figure S5. Eltanexor-treatment is well-tolerated in Apcmin/+ mice.

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Evans et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc71f https://doi.org/10.1158/2767-9764.29568695

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Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 5 from The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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