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July 15, 2025Journal of Clinical MedicineOpen Access

Evaluation of Pre-Pectoral Direct-to-Implant Breast Reconstruction with Post-Mastectomy Radiation: A Systematic Review and Meta-Analysis

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Authors

NPNisha ParmeshwarUniversity of California, San FranciscoJKJacquelyn KnoxUniversity of California, San FranciscoMPMerisa PiperUniversity of California, San Francisco

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Overview

Systematic review shows post-mastectomy radiation increases risks of complications in breast reconstruction, highlighting patient care challenges.

Key Points

  • Post-mastectomy radiation significantly raises odds of complications in breast reconstruction, including infection and capsular contracture.
  • Meta-analysis of seven studies revealed an odds ratio of 2.76 for infection linked to post-mastectomy radiation exposure.
  • Evaluation covered 343 patients who underwent direct-to-implant reconstruction and received post-mastectomy radiation.
  • Findings emphasize the need for careful pre-operative counseling regarding potential risks of post-mastectomy radiation on breast reconstruction outcomes.

Cite This Study

Parmeshwar et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc82bhttps://doi.org/10.3390/jcm14145004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Relationship of Radiation Therapy Parameters and Perioperative Morbidity and Toxicities on Breast Reconstruction Outcomes2026
  2. 2Study on the Impact of Post-Mastectomy Radiotherapy on Immediate Breast Reconstruction and Complications: A Meta-Analysis2024 · 1 citations
  3. 3Patient-Reported Outcomes and Complication Profiles of Implant-Based Breast Reconstruction in Patients With Postmastectomy Radiation Therapy2024 · 3 citations
  4. 4Direct-to-implant versus two-stage implant-based breast reconstruction in patients requiring postmastectomy radiotherapy2025
  5. 5The Impact of Postmastectomy Radiation Therapy on Immediate Prepectoral Reconstruction with Polyurethane-Coated Implants2025 · 2 citations