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July 22, 2025

Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes

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Authors

LKLeena KadamKCKaylee ChanETEthan Tawater

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Overview

Research reveals distinct effects of obesity and gestational diabetes on placental mitochondria, suggesting complex sex-specific mechanisms.

Key Points

  • Maternal obesity and gestational diabetes disrupt placental mitochondria, affecting energy production.
  • Significant changes in mitochondrial protein expression were found in placentas of obese women compared to lean.
  • Fetal sex influenced mitochondrial structure dynamics, with notable declines in fission in OB and GDM placentas.
  • Obesity partially activates mitophagy pathways, but GDM placentas do not show similar responses, indicating impaired function.

Cite This Study

Kadam et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd7d3https://doi.org/10.1101/2025.07.17.665416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta2025
  2. 2Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes2024 · 5 citations
  3. 3Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta2025
  4. 4Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism2024
  5. 5Redox imbalance and mitochondrial dysfunction in gestational diabetes mellitus: Implications for maternal health, placental function, and offspring metabolic programming2026