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October 10, 2025Open Access

Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta

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Authors

RWR. WangJLJianying LiuQLQian Li

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Overview

Study reveals that obesity with gestational diabetes disrupts mitochondrial and ER interactions, indicating placental dysfunction.

Key Points

  • Obesity concurrent with gestational diabetes leads to increased apoptosis in placental tissues.
  • Reduced trophoblast cell count and disorganized cell arrangement noted in placenta from affected mothers.
  • Elevated oxidative stress and ER stress markers were found in placentas of women with obesity and GDM.
  • Increased formation of mitochondrial-endoplasmic reticulum contacts correlated with placental dysfunction.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68e861b07ef2f04ca37e4ab7https://doi.org/10.21203/rs.3.rs-7658198/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta2025
  2. 2Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes2025
  3. 3Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes2024 · 13 citations
  4. 4Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes2017 · 104 citations
  5. 5Effects of Gestational Metabolic Abnormalities on Placenta2025