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December 13, 2025Scientific ReportsOpen Access

Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta

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Authors

RWR. WangJLJianying LiuQLQian Li

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Overview

Pilot study reveals obesity with GDM induces trophoblast apoptosis, indicating oxidative stress's role in placental dysfunction.

Key Points

  • This study examines the impact of obesity concurrent with gestational diabetes on placental dysfunction.
  • Analyzed term placental tissues from women with obesity and gestational diabetes or healthy controls.
  • Assessed cell count, arrangement, and apoptosis in placental trophoblasts.
  • Measured oxidative stress and protein expression of ER stress markers and MERC complexes.”],
  • results
  • Reduced trophoblast cell count and disorganized cell arrangement observed in GDM group.
  • Increased apoptosis rate in obesity and GDM placental tissues compared to controls.
  • Upregulation of oxidative stress and ER stress marker proteins noted compared to healthy controls.
  • Proximity ligation assay indicated increased MERCs assembly in obesity with GDM.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6941aaa70f5af7fd17df4c0fhttps://doi.org/10.1038/s41598-025-31193-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta2025
  2. 2Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes2025
  3. 3Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes2024 · 5 citations
  4. 4Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes2017 · 104 citations
  5. 5Effects of Gestational Metabolic Abnormalities on Placenta2025