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July 23, 2025ToxinsOpen Access

The Impact of Strength Changes on Active Function Following Botulinum Neurotoxin-A (BoNT-A): A Systematic Review

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Authors

RGRenée GillMBMegan BankyZYZonghan Yang

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Overview

Systematic review evaluates the relationship between muscle strength and active function in adults with spasticity, highlighting challenges in analysis.

Key Points

  • The review analyzed 17 studies involving 677 participants receiving botulinum neurotoxin-A injections for spasticity.
  • No significant relationship was found between changes in muscle strength and improvements in active function after treatment.
  • Quality assessment indicated fair to good ratings for included studies using established checklists.
  • Heterogeneity in strength measures and variability in treatment factors limited the ability to conclude on effective outcome relationships.

Cite This Study

Gill et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cddf3https://doi.org/10.3390/toxins17080362
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-Invasive Assessment of Hypertonic Muscle Properties After Botulinum Toxin Neuromodulation in Post-Stroke Patients: A Systematic Literature Review of Recent Evidence (2023–2025) on Mobility and Balance2026
  2. 2ABSTRACT NUMBER: ESOC2026A440 SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A FOR LOWER LIMB SPASTICITY IN POST-STROKE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS2026
  3. 3Effects of lower limb botulinum toxin injections on gait functional outcomes in stroke survivors: a systematic review and meta-analysis2025
  4. 4Use of Botulinum Toxin in the Treatment of Patients with Upper Limb Spasticity After Stroke – a Systematic Review2025
  5. 5Enhancing Cardiopulmonary Function Through Spasticity Reduction—Effects of Botulinum Toxin A After Stroke: A Prospective Before–After Study2026 · 1 citations