A Review of Metformin's Anti-aging Mechanisms

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This review examines metformin's anti-aging properties through mechanisms like AMPK activation, indicating therapeutic potential for longevity.

Metformin exhibits anti-aging effects, potentially extending lifespan through multiple cellular pathways.
The review highlights mechanisms such as AMPK activation, sirtuin stimulation, and mTOR inhibition as key factors.
Animal and cellular models demonstrate the efficacy of metformin’s anti-aging mechanisms in scientific research.
Understanding metformin's diverse effects offers insights into future clinical trials and therapeutic options for aging.

Zhenying Zhao (2025) studied this question.

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This review examines metformin's anti-aging properties through mechanisms like AMPK activation, indicating therapeutic potential for longevity.