What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

This review examines how pharmacogenomic and epigenetic influences affect metformin's efficacy in promoting longevity.

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Review finds pharmacogenomic and epigenetic factors influence metformin's effects on aging and longevity.

This review examines how pharmacogenomic and epigenetic influences affect metformin's efficacy in promoting longevity.
Systematic search of studies from multiple databases like PubMed and Scopus.
Qualitative synthesis of literature regarding metformin's impact on aging.
Review discusses pharmacogenomic variants and epigenetic modifications related to metformin.
Metformin's effects on aging vary due to genetic factors and pharmacogenomic variants.
Epigenetic changes from metformin influence pathways related to oxidative stress and mitochondrial function.
Emerging trials aim to optimize metformin's use in different aging populations.

Alam et al. (2026) studied this question.

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