What question did this study set out to answer?

This review aims to explore the wider therapeutic potential of metformin beyond diabetes management, particularly its anti-aging and anti-cancer properties.

July 1, 2026Open Access

Metformin Beyond Diabetes: A Comprehensive Pharmacological Review of the Anti-Aging and Anti-Cancer Pleiotropy, the Ampk/Mtor and Mitochondrial Mechanisms, the Tame Trial, and the Critical Appraisal of Gero Protection and Oncological Repurposing

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Authors

BSBachu Bhavani1*, Velpula Pranitha1, Lakshmi Manisha1, Muvvala Sudhakar2

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Implication

Review examines metformin's effects on aging and cancer, highlighting evidence and challenges within clinical contexts.

Key Points

This review aims to explore the wider therapeutic potential of metformin beyond diabetes management, particularly its anti-aging and anti-cancer properties.
Critical examination of molecular mechanisms and pathways involved in metformin's actions
Evaluation of observational studies and randomized controlled trials regarding anti-cancer effects
Discussion of the TAME trial and its implications for geroprotective interventions.
Metformin shows potential anti-cancer benefits, but many studies suffer from methodological limitations
Randomized trials have largely provided inconclusive results regarding cancer prevention and treatment
The TAME trial aims to assess metformin's role in delaying onset of age-related diseases.

Cite This Study

Bachu Bhavani1*, Velpula Pranitha1, Lakshmi Manisha1, Muvvala Sudhakar2 (2026) studied this question.

synapsesocial.com/papers/6a44af055cd2549c8bc44128 https://doi.org/10.5281/zenodo.21036828

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Metformin Beyond Diabetes: A Comprehensive Pharmacological Review of the Anti-Aging and Anti-Cancer Pleiotropy, the Ampk/Mtor and Mitochondrial Mechanisms, the Tame Trial, and the Critical Appraisal of Gero Protection and Oncological Repurposing

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Key Points

Cite This Study

Metformin Beyond Diabetes: A Comprehensive Pharmacological Review of the Anti-Aging and Anti-Cancer Pleiotropy, the Ampk/Mtor and Mitochondrial Mechanisms, the Tame Trial, and the Critical Appraisal of Gero Protection and Oncological Repurposing

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