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July 28, 2025

Cost-Benefit Analysis of Interpersonal Therapy and Fluoxetine for Treating Depression and PTSD in Primary Care Settings in Kenya

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Authors

EOEaster OlwandaDMDaniel MwaiMMMuthoni Mathai

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Overview

Cost-benefit analysis compares productivity gains from IPT and fluoxetine in treating depression and PTSD in primary care, highlighting FLX's better outcomes.

Key Points

  • Core finding indicates that both IPT and fluoxetine yield greater productivity gains than their treatment costs.
  • Participants receiving IPT averaged a gain of 16,242 KES, while FLX participants gained 13,239 KES in the first year.
  • Using a randomized trial design, 1,918 adults participated in this analysis of depression and PTSD therapies.
  • Results suggest fluoxetine has a more favorable benefit-to-cost ratio than interpersonal therapy over a decade.

Cite This Study

Olwanda et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceb4ahttps://doi.org/10.21203/rs.3.rs-6977800/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-specialist interpersonal psychotherapy versus fluoxetine for major depression and post-traumatic stress disorder in Kenyan public-sector primary care: a sequential, multiple-assignment, randomised trial2026 · 2 citations
  2. 2“The peace that I wanted, I got”: Qualitative insights from patient experiences of SMART DAPPER interventions for major depression and traumatic stress disorders in Kenya2024 · 1 citations
  3. 3Effectiveness of Psychotherapy vs Antidepressants for Depression in Primary Care in India: A Randomized Pilot Trial2025
  4. 4The Cost Effectiveness of Treatment Strategies for Depression in Ethiopia: A Multiple Cohort Markov Model Analysis2026
  5. 5Cost-effectiveness of therapist-assisted internet-delivered psychological therapies for PTSD differing in trauma focus in England: an economic evaluation based on the STOP-PTSD trial2024 · 6 citations