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July 29, 2025

Maternal sucrose intake during pregnancy alone disrupts testosterone and allopregnanolone levels in the fetal brain of rats

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Authors

MJMinseon M JungMIMarwa IdrissiYHYen-Nhi Hoang

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Overview

Research demonstrates that maternal high-sucrose diet alters testosterone and allopregnanolone in the fetal brain, suggesting potential impacts on development.

Key Points

  • Maternal sucrose intake did not change body mass or litter size, but increased male offspring percentage.
  • High-sucrose diet significantly elevated testosterone in the fetal nucleus accumbens region.
  • Allopregnanolone levels decreased in the fetal amygdala with maternal high-sucrose diet.
  • Findings highlight the sensitivity of fetal brain steroid levels to maternal diet during pregnancy.

Cite This Study

Jung et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cecf2https://doi.org/10.1101/2025.07.21.664469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 17561 Maternal Sucrose Consumption During Gestation Alone Does Not Affect Glucocorticoids and Aldosterone in the Fetal Brain and Blood of Rats2024
  2. 2Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats2025
  3. 3Differential effects of perigestational consumption of sucrose‐sweetened beverages on anxiety and depression‐related behaviors in adult offspring: Sex disparity in a mouse model2024
  4. 4Long-term consequences of prenatal saccharin exposure: evidence of sex-specific molecular programing in the prefrontal cortex and behavior of adolescent rats2026
  5. 5A high‐fat, high‐sugar diet impairs maternal metabolism throughout pregnancy and lactation in mice2026