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July 30, 2025BiologyOpen Access

Immunological Factors in Recurrent Pregnancy Loss: Mechanisms, Controversies, and Emerging Therapies

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Authors

EMEfthalia MoustakliAPAnastasios PotirisAZAthanasios Zikopoulos

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Overview

Review reveals immunological factors drive recurrent pregnancy loss in IVF, suggesting new therapies and diagnostics for tailored patient care.

Key Points

  • Recurrent pregnancy loss affects 1-2% of women trying to conceive naturally, and 10-15% undergoing IVF.
  • An imbalance in maternal immunological tolerance can lead to miscarriage and implantation failure during pregnancy.
  • Emerging therapies like precision immunotherapies and novel cytokine modulators may enhance pregnancy success rates.
  • Future research must focus on clinical trials and standardized assessments to improve therapeutic consistency in immunological treatment.

Cite This Study

Moustakli et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cedaehttps://doi.org/10.3390/biology14070877
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