Figure 2 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Multiple cell types within the immune TME are affected by the type 1 IFN response as shown by CosMx SMI, including distinct macrophage subtypes of differing polarity. A, Spatial reconstruction of the TME. B, Macrophage polarization. A, The IFN signature associated with a reconstructed region of the TME. B, Spatial profiling revealed upregulation of several populations associated with a proinflammatory phenotype, including Macrophage_CXCL10, Macrophage_C1QB, and downregulation of anti-inflammatory Macrophage_SPP1 cells after treatment with dazostinag alone. Combination with chemotherapy maintained a more immune-suppressive TME.