Supplementary Figure S7 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Richard C. Gregory; Neil Lineberry; Alexander Parent; Karthik Rajasekaran; Thomas J. Ow; Cherie‐Ann O. Nathan; Beryl A. Hatton; Wendy Jenkins; Marc Grenley; Connor Burns; Angela Merrell; Jason P. Frazier; Jonathan M.J. Derry; Emily Beirne; Richard A. Klinghoffer

doi:10.1158/2767-9764.29672746

July 30, 2025

Supplementary Figure S7 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

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Key Points

MAIN FINDING: Type 1 IFN response significantly influences multiple immune cell types within the tumor microenvironment.
KEY EVIDENCE: CosMx SMI analysis reveals distinct macrophage subtypes varying in polarity affected by the immune response.
APPROACH: Immune tumor microenvironment evaluated in patients with head and neck squamous cell carcinoma alongside chemotherapy.
SIGNIFICANCE: Understanding these interactions could enhance therapeutic strategies targeting the tumor microenvironment.

Implication

Supplementary figure highlights how type 1 IFN response affects immune microenvironment, implying diverse macrophage roles in therapy.

Abstract

Figure S7. Multiple cell types within the immune TME are affected by type 1 IFN response as shown by CosMx SMI including distinct macrophage subtypes of differing polarity.

Discussion

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Cite This Study

Gregory et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf41c https://doi.org/10.1158/2767-9764.29672746

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Supplementary Figure S7 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S7 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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