August 1, 2025Open Access

Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis

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Review highlights structural biology of SINV, focusing on glycoproteins and their role in pathogenesis and immune evasion.

Sindbis virus is a globally recognized alphavirus causing febrile rash and arthritis in humans.
The virion's T=4 icosahedral architecture comprises a nucleocapsid core and glycoprotein shell.
Key proteins include Capsid, E1, and E2, crucial for viral entry and host interaction during pathogenesis.
Understanding SINV structural data could aid in developing antiviral therapies and vaccines against alphaviruses.

Geng et al. (2025) studied this question.

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