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September 5, 2025International Journal of Molecular SciencesOpen Access

Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis

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Authors

QGQibin GengUniversity of MinnesotaCNChanakha K. NavaratnarajahMayo Clinic in ArizonaWZWei ZhangZhejiang Chinese Medical University

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Implication

This review highlights key structural features of Sindbis virus, revealing implications for pathogenesis and protein function.

Key Points

  • SINV structural proteins are critical for virion architecture and drive essential processes like host cell entry.
  • The E1 glycoprotein is a class II fusion protein, playing a crucial role in membrane fusion during infection.
  • Genetic variations in the E2 gene impact immune evasion and influence the development of arthritogenic and neurovirulent diseases.
  • High-resolution imaging techniques, such as cryo-electron microscopy, are vital for advancing our understanding of SINV biology.

Cite This Study

Geng et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc95638ahttps://doi.org/10.3390/ijms26178323
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