Key result
Epitope mapping identified six common B-cell epitopes in SINV infection, located in the capsid, E2, E1, and PE2 regions, with one capsid epitope sharing sequence identity with the MIF receptor.
Population
SINV IgG-positive and IgG-negative serum pools, and individual patient sera (n=22)
Comparison
Probing with a library of linear 18-mer peptides… vs SINV IgG-negative serum pools
Design
Preclinical
Authors
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May inform SINV vaccine or diagnostic development; leaves open clinical relevance of capsid-MIF mimicry.
Identifies six common human B-cell epitopes for Sindbis virus, highlighting a potential role for uncleaved PE2 and a MIF receptor mimotope in SINV infection.
Adouchief et al. (2016) studied Sindbis virus (SINV) infection (n=22). Epitope mapping using linear 18-mer peptides vs. SINV IgG-negative serum pools was evaluated on Identification of common B-cell epitopes. Epitope mapping identified six common B-cell epitopes in SINV infection, located in the capsid, E2, E1, and PE2 regions, with one capsid epitope sharing sequence identity with the MIF receptor.
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