Figure S6 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Stephen L. DeAngelo; Liang Zhao; Sofia Dziechciarz; Myungsun Shin; Sumeet Solanki; Andrii Balia; Marwa O. El-Derany; Cristina Castillo; Yao Qin; Nupur K. Das; Hannah N. Bell; João A. Paulo; Yuezhong Zhang; Nicholas J. Rossiter; Elizabeth C. McCulla; Jianping He; Indrani Talukder; Wai‐Lung Ng; Zachary T. Schafer; Nouri Neamati; Joseph D. Mancias; Markos Koutmos; Yatrik M. Shah

doi:10.1158/0008-5472.29761160

Key Points

MAIN FINDING: Selenoproteins play a significant role in the tumor suppressive mechanism for colorectal cancer.
KEY EVIDENCE: CRISPR analyses show co-essentiality between selenoproteins and tumor viability in CRC.
APPROACH: Methods include qPCR validation of AlkBH8 knockdown and survival analysis of related biosynthetic pathways.
SIGNIFICANCE: Finding druggable pathways in the selenoproteome may provide new treatment strategies for colorectal cancer.

Implication

Analysis shows selenoprotein function is crucial in colorectal cancer, implying potential drug targets.

Abstract

Supplementary Figure S6 explores the functional importance of selenoproteins in CRC via CRISPR co-essentiality analyses, qPCR validations of AlkBH8 KD, and survival analyses of tRNA-sec biosynthetic pathway genes.

Discussion

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Cite This Study

DeAngelo et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfca3 https://doi.org/10.1158/0008-5472.29761160

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Figure S6 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S6 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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