Figure S3 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Stephen L. DeAngelo; Liang Zhao; Sofia Dziechciarz; Myungsun Shin; Sumeet Solanki; Andrii Balia; Marwa O. El-Derany; Cristina Castillo; Yao Qin; Nupur K. Das; Hannah N. Bell; João A. Paulo; Yuezhong Zhang; Nicholas J. Rossiter; Elizabeth C. McCulla; Jianping He; Indrani Talukder; Wai‐Lung Ng; Zachary T. Schafer; Nouri Neamati; Joseph D. Mancias; Markos Koutmos; Yatrik M. Shah

doi:10.1158/0008-5472.29761175

Key Points

MAIN FINDING: The study identifies the selenoproteome as a potentially druggable pathway in colorectal cancer.
KEY EVIDENCE: RSL3 targets are validated through AP-MS proteomic analysis, indicating specific protein interactions.
APPROACH: Selenoprotein expression was assessed following selenium supplementation to track changes.
SIGNIFICANCE: This research uncovers new avenues in colorectal cancer therapy through targeted pathways like the selenoproteome.

Implication

Supplementary figure validates selenoprotein expression and reveals RSL3 targets via proteomic analysis, suggesting new treatment approaches.

Abstract

Supplementary Figure S3 shows selenoprotein expression validations upon selenium supplementation and identifies RSL3 targets through AP-MS proteomic analysis.

Discussion

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Cite This Study

DeAngelo et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfc87 https://doi.org/10.1158/0008-5472.29761175

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Figure S3 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S3 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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