Figure S1 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Stephen L. DeAngelo; Liang Zhao; Sofia Dziechciarz; Myungsun Shin; Sumeet Solanki; Andrii Balia; Marwa O. El-Derany; Cristina Castillo; Yao Qin; Nupur K. Das; Hannah N. Bell; João A. Paulo; Yuezhong Zhang; Nicholas J. Rossiter; Elizabeth C. McCulla; Jianping He; Indrani Talukder; Wai‐Lung Ng; Zachary T. Schafer; Nouri Neamati; Joseph D. Mancias; Markos Koutmos; Yatrik M. Shah

doi:10.1158/0008-5472.29761184

Key Points

MAIN FINDING: The research identifies the selenoproteome as a potential druggable pathway in colorectal cancer.
KEY EVIDENCE: CETSA assays demonstrate GPX4 stability and its role in CRC cell growth responses to RSL3 treatment.
APPROACH: The study utilized CETSA assays to assess GPX4 stability and CRC response to RSL3 with Liproxstatin-1.
SIGNIFICANCE: These findings unveil new therapeutic strategies targeting the selenoproteome in colorectal cancer treatment.

Implication

Supplementary data reveals GPX4 stability and CRC growth responses to RSL3, indicating a potential druggable target.

Abstract

Supplementary Figure S1 shows GPX4 stability using CETSA assays and CRC cell growth responses to RSL3 treatment, with or without Liproxstatin-1 rescue.

Discussion

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Cite This Study

DeAngelo et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfc83 https://doi.org/10.1158/0008-5472.29761184

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Figure S1 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S1 from Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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