August 1, 2025BMJ OpenOpen Access

Comorbidities and incidence of heart failure with preserved ejection fraction: a systematic review and meta-analysis of cohort studies

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Discussion

Systematic review highlights comorbidities like atrial fibrillation and hypertension as significant HFpEF risk factors.

Five comorbidities are identified as significant risks for developing heart failure with preserved ejection fraction.
Atrial fibrillation showed the highest hazard ratio at 2.92, indicating a strong association with incident HFpEF.
Cohort studies with adults without prior heart failure were analyzed using random-effects models for data synthesis.
Identifying these comorbidities can aid in early risk stratification and targeted preventive management of HFpEF.

Li et al. (2025) studied this question.

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