Association Between Cardiovascular vs. Non-Cardiovascular Co-Morbidities and Outcomes in Heart Failure with Preserved Ejection Fraction
Key result
Non-cardiovascular co-morbidities, rather than cardiovascular ones, independently predicted the primary outcome of HF hospitalization or all-cause mortality, which occurred in 50% of HFPEF patients.
Population
539 patients with acute heart failure, median age 79, 56% women, multinational.
Design
Cohort
Follow-up
18 months
Authors
Discussion
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Member takes
Implication
May inform risk stratification in HFpEF; hypothesis-generating and requires prospective validation.
Study Design
Type
Observational (n=539)
Multicenter
Yes
Structured PICO
P
Population
539 patients with acute heart failure (Framingham criteria, LVEF ≥ 45%, and NT-pro-BNP ≥ 300 ng/L or BNP ≥ 100 ng/L), median age 79, 56% women, multinational.
O
Outcome
Composite of heart failure hospitalization or all-cause mortality at 18 monthscomposite
In patients with HFpEF, non-cardiovascular comorbidities are stronger independent predictors of mortality and heart failure hospitalization than cardiovascular comorbidities.
Cite This Study
Lund et al. (2014) conducted an observational in Heart failure with preserved ejection fraction (HFPEF) (n=539). Cardiovascular and non-cardiovascular co-morbidities was evaluated on HF hospitalization or all-cause mortality. Non-cardiovascular co-morbidities, rather than cardiovascular ones, independently predicted the primary outcome of HF hospitalization or all-cause mortality, which occurred in 50% of HFPEF patients.