Prevalence and Prognostic Impact of Non-Cardiac Co-Morbidities in Heart Failure Outpatients with Preserved and Reduced Ejection Fraction: A Community-Based Study
Key result
An increasing number of non-cardiac co-morbidities was associated with a higher risk for all-cause mortality (HR 1.25; 95% CI 1.10-1.26; P<0.001), with similar contributions in HFrEF and HFpEF.
Population
2314 patients with chronic heart failure, mean age 77 ±10 years, 57% men.
Design
Cohort
Follow-up
median 31 (interquartile range 16-41) months
Authors
Discussion
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Implication
Non-cardiac comorbidities warrant attention in HF care regardless of LVEF; supports equivalent prognostic role in HFrEF and HFpEF.
Study Design
Type
Cohort (n=2,314)
Structured PICO
P
Population
2,314 outpatients with chronic heart failure (mean age 77 years, 43% female), followed for a median of 31 months.
O
Outcome
All-cause mortality, all-cause hospitalization, heart failure hospitalization, non-cardiovascular hospitalizationhard clinical
Main Result
Hazard Ratio: 1.25 (95% CI 1.1–1.26)
p-value: p=< 0.001
Non-cardiac comorbidities confer a similar prognostic burden in both HFrEF and HFpEF, suggesting that optimizing comorbidities is equally important across the LVEF spectrum.
Cite This Study
Senni et al. (2018) conducted a cohort in Chronic heart failure (HFrEF and HFpEF) (n=2,314). Increasing number of non-cardiac co-morbidities vs. Fewer non-cardiac co-morbidities was evaluated on All-cause mortality (HR 1.25, 95% CI 1.10-1.26, p=< 0.001). An increasing number of non-cardiac co-morbidities was associated with a higher risk for all-cause mortality (HR 1.25; 95% CI 1.10-1.26; P<0.001), with similar contributions in HFrEF and HFpEF.