August 1, 2025

Optimising Migraine Treatment Through Non-invasive Brain Stimulation: A Systematic Review of NIBS Applications and Pharmaceuticals

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Discussion

Systematic review compares neuromodulation and pharmaceuticals in migraine prophylaxis, suggesting less side effects with effective results.

Neuromodulation, specifically transcranial direct current stimulation, shows significant efficacy in reducing migraine frequency and severity.
A total of 35 randomised controlled trials were included, with neuromodulation consistently outperforming traditional pharmaceuticals.
CGRP-mAbs were identified as effective pharmaceuticals with fewer adverse events compared to other treatments.
Future research should standardize protocols and focus on larger trials to validate these findings in migraine prevention.

Atalan et al. (2025) studied this question.

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Systematic review compares neuromodulation and pharmaceuticals in migraine prophylaxis, suggesting less side effects with effective results.