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August 2, 2025

Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: An individual patient-level meta-analysis of randomised trials

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Authors

ACAsgher ChampsiSFSebastian FoxEHEvan J Hardy

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Overview

Meta-analysis reveals increased mortality in non-white patients with heart failure and atrial fibrillation, indicating significant health disparities.

Key Points

  • Non-white patients with heart failure experience higher mortality rates compared to white patients.
  • The combination of heart failure and atrial fibrillation increases the mortality hazard ratio for non-white patients to 2.05.
  • Analysis included 16,713 patients from 12 randomized trials, focusing on ethnicity and comorbidity effects.
  • Findings highlight the critical need for targeted interventions to address ethnicity-related health disparities in heart failure.

Cite This Study

Champsi et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8cffbdhttps://doi.org/10.1101/2025.07.31.25332510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: an individual patient-level meta-analysis of randomized trials2026
  2. 296 The impact of ethnicity on clinical outcomes in patients with heart failure and atrial fibrillation2024
  3. 3Ethnic Differences in Atrial Fibrillation Among Patients with Heart Failure in Asia2020 · 11 citations
  4. 4Association of Race and Ethnicity With Stroke and Mortality Outcomes in Atrial Fibrillation2025 · 2 citations
  5. 5Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific2019 · 24 citations