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August 1, 2025

Supplementary Figure 2 from Moxidectin Unravels the Role of the Hippo–YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme

Itishree Kaushik Robin Rajan Shreyas Gaikwad Mohamed A. Eltokhy Sanjay Srivastava

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Key Points

MAIN FINDING: Moxidectin interacts with the hippo-yap pathway, affecting immune responses in glioblastoma.
KEY EVIDENCE: FACS analysis demonstrates the levels of immunosuppression within the tumor microenvironment.
APPROACH: The study leveraged FACS analysis to assess immune cell populations in the glioblastoma TME.
SIGNIFICANCE: Understanding moxidectin's role may lead to improved therapeutic strategies for glioblastoma management.

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Implication

FACS analysis reveals immunosuppression in the TME, suggesting moxidectin's influence on glioblastoma immunity.

Abstract

Supplementary Figure 2: FACS analysis of immunosuppression in the TME.

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Cite This Study

Kaushik et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01ca https://doi.org/10.1158/1535-7163.29760428

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from Moxidectin Unravels the Role of the Hippo–YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme2025
2Supplementary Figure 3 from Moxidectin Unravels the Role of the Hippo–YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme2025
3Data from Moxidectin Unravels the Role of the Hippo–YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme2025
4Supplementary Figure S2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025