⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

September 11, 2025

Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

View Full Paper

Ask AI

Bookmark

Share

Key Points

Inhibition of fibulin-3 enhances macrophage activation in glioblastoma, showing potential for immunotherapy.
Knockdown of fibulin-3 does not alter certain immune checkpoint expressions, indicating selective immune pathway effects.
Findings may lead to new therapeutic strategies targeting fibulin-3 in glioblastoma, addressing immune evasion.
The results highlight the significance of extracellular matrix modifiers like fibulin-3 in cancer immunology.

Implication

Inhibition of fibulin-3 reduces immunosuppressive signaling in glioblastoma, suggesting new treatment targets.

Abstract

Figure S4. Fibulin-3 knockdown does not affect the expression of some immune checkpoints.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa548a6 https://doi.org/10.1158/2767-9764.30102525

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025