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September 11, 2025

Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Anti-fibulin-3 treatment led to decreased immunosuppressive signaling in glioblastoma, enhancing immune activity.
Notable increases in macrophage activation were observed during treatment with anti-fibulin-3.
Findings suggest a potential therapeutic strategy targeting fibulin-3 to improve immune response in glioblastoma.
The research highlights the role of fibulin-3 in mediating immunosuppressive signals within the tumor microenvironment.

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Implication

Experimental findings reveal that anti-fibulin-3 treatment decreases immunosuppression in glioblastoma, suggesting enhanced immune responses.

Abstract

Figure S7. Anti-fibulin-3 treatment decreases immunosuppression in GBM.

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa54925 https://doi.org/10.1158/2767-9764.30102513

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025