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September 11, 2025

Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 enhances macrophage activation related to glioblastoma behavior.
Reducing immunosuppressive signaling within the tumor microenvironment improves immune response.
This research methodology involved characterizing fibulin-3 effects in fibulin-3-null cells.
The findings suggest anti-fibulin-3 targeting could potentially improve therapeutic strategies.

Implication

Characterization of fibulin-3 effects reveals reduced immunosuppressive signaling and enhanced macrophage activation in glioblastoma.

Abstract

Figure S5. Characterization of fibulin-3 effects and anti-fibulin-3 targeting in fibulin-3-null cells.

Discussion

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa5492f https://doi.org/10.1158/2767-9764.30102522

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025