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September 11, 2025

Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 elevates macrophage activation, leading to an enhanced immune response against glioblastoma.
Key finding shows that anti-fibulin-3 treatment increases myeloid cell attack on glioblastoma cells, suggesting potential therapeutic implications.
Observational analysis reveals the impact of fibulin-3 on immunosuppressive pathways in glioblastoma, indicating a novel target for immunotherapy.
These findings highlight the potential of targeting fibulin-3 in glioblastoma treatment to boost anti-tumor immunity.

Implication

Inhibition of fibulin-3 enhances macrophage activation, indicating a shift in immunosuppressive signaling in glioblastoma.

Abstract

Supplementary Figure S9. Anti-fibulin-3 triggers myeloid cell attack against syngeneic GBM cells.

Discussion

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa54929 https://doi.org/10.1158/2767-9764.30102507

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025