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September 11, 2025

Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 increases macrophage activation and reduces immunosuppressive signaling in glioblastoma.
Anti-fibulin-3 treatment promoted phagocytosis of GBM cells by macrophages in vitro, indicating enhanced immune response.
The study assessed signaling pathways to explore the role of fibulin-3 in macrophage activity against glioblastoma.
These findings highlight fibulin-3 as a potential target for immunotherapy in glioblastoma treatment strategies.

Implication

Supplementary evidence shows that reducing fibulin-3 boosts macrophage activation and reduces immunosuppressive signaling.

Abstract

Figure S10. Anti-fibulin-3 promotes in vitro phagocytosis of GBM cells by macrophages.

Discussion

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa548a3 https://doi.org/10.1158/2767-9764.30102534

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025