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September 11, 2025

Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 reduces immunosuppressive signaling and increases macrophage activation in glioblastoma.
The study reveals a significant correlation between fibulin-3 expression and immunosuppressive signals.
Fibulin-3 plays a critical role in the extracellular matrix of glioblastoma, influencing macrophage behavior.
Macrophage activation is essential in alleviating the immune suppression typically seen in glioblastoma.

Implication

Figure shows correlation of fibulin-3 with immunosuppressive signals in glioblastoma, indicating effects on macrophages.

Abstract

Figure S3. Correlation of fibulin-3 expression with immunosuppressive signals in GBM.

Discussion

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa548b1 https://doi.org/10.1158/2767-9764.30102528

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025