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September 11, 2025

Supplementary Figure S6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 enhances macrophage activation in glioblastoma, promoting immune response.
Increased binding of p65/RelA to the CSF1 promoter suggests elevated signaling pathways.
Extracellular matrix protein modulation influences tumor microenvironment in glioblastoma.
Findings may inform new therapeutic strategies targeting immunosuppression in glioblastoma.

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Implication

Inhibition of fibulin-3 increases macrophage activation and reduces immunosuppressive signaling in glioblastoma.

Abstract

Figure S6. Fibulin-3 induces p65/RelA binding to the CSF1 promoter.

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa5492c https://doi.org/10.1158/2767-9764.30102516

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025