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September 11, 2025

Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 significantly enhances macrophage activation, improving immune response in glioblastoma.
Macrophage signals lead to upregulation of fibulin-3, indicating a potential immunosuppressive mechanism.
The study suggests that targeting fibulin-3 could disrupt immunosuppressive pathways in glioblastoma tumors.
Findings highlight the interplay between fibulin-3 and macrophage activity in the context of tumor immunity.

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Implication

Inhibition of fibulin-3 reduces immunosuppressive signaling and enhances macrophage activity in glioblastoma.

Abstract

Figure S8. Fibulin-3 is upregulated by macrophage signals.

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa5492e https://doi.org/10.1158/2767-9764.30102510

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025