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September 11, 2025

Supplementary Figure S2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma

Somanath Kundu Soham Mitra Arivazhagan Roshini John A. Longo Sharon L. Longo Abigail G. Venskus Harish Babu Mariano S. Viapiano

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Key Points

Inhibition of fibulin-3 leads to increased macrophage activation in glioblastoma tumors, enhancing anti-tumor activity.
Quantitative immunohistochemistry data shows significant differences in tumor-associated macrophages in treated vs. untreated samples.
This analysis highlights a potential therapeutic target in the extracellular matrix components for glioblastoma treatment.
The findings imply that targeting fibulin-3 may improve immunotherapeutic strategies in glioblastoma patients.

Implication

Analysis reveals that inhibiting fibulin-3 reduces immunosuppressive signaling, suggesting enhanced macrophage activity in glioblastoma.

Abstract

Figure S2. Analysis of TAMs in intracranial tumors by quantitative immunohistochemistry.

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Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3031b076d99fa548c0 https://doi.org/10.1158/2767-9764.30102531

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
2Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
3Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
4Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025
5Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma2025