Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759780

Key Points

Tumor suppressor genes with segmental duplications are more likely to undergo somatic deletions and structural variations.
A long-read sequencing meta-analysis was conducted to analyze somatic alterations in tumor suppressor genes.
Size-matching was applied before and after the analysis to ensure accurate comparison of findings.
Understanding these genetic changes can help in comprehending cancer development and susceptibility.

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Implication

Long-read sequencing meta-analysis reveals somatic deletions and structural variations in tumor suppressor genes with segmental duplications, suggesting susceptibility to genetic changes.

Abstract

Long-read sequencing meta-analysis of somatic alterations in TSGs with SDs before/after size-matching.

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Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0292 https://doi.org/10.1158/0008-5472.29759780

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Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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