Supplementary Figure 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759750

Key Points

Main finding shows tumor suppressor genes with segmental duplications have a higher deletion rate compared to those without.
Key evidence comes from a meta-analysis of 33 cancer types that utilized GISTIC scores to assess deletion propensity.
The approach involved analyzing genome data to compare deletion frequency in tumor suppressor genes based on their structural features.
This work enhances understanding of genetic vulnerabilities in cancer, pointing to segmental duplications as a significant risk factor.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Meta-analysis reveals higher deletion propensity in tumor suppressor genes with segmental duplications, indicating a vulnerability in various cancer types.

Abstract

Meta-analysis of 33 TCGA cancer types showing higher deletion propensity (GISTIC scores) for TSGs with SDs versus TSGs without SDs, independent of gene size.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02b6 https://doi.org/10.1158/0008-5472.29759750

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading