Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Q: What type of study is this?

This is a Quantitative Study study.

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka–Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.30235119

Key Points

Homozygous deletion frequency positively correlates with SD repeat number in tumor suppressor genes.
Evaluation across 33 cancer types from the TCGA reveals significant structural variations.
Segmental duplications may contribute to increased somatic deletions observed in cancers.
Findings indicate potential mechanisms for genomic instability in cancer development.

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Implication

Analysis shows increased homozygous deletion frequency in segmental duplication-containing tumor suppressor genes, highlighting structural variations in cancer.

Abstract

Positive correlation between SD repeat number and homozygous deletion frequency in SD-containing TSGs across 33 TCGA cancers.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb1629 https://doi.org/10.1158/0008-5472.30235119

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Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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