Supplementary Figure 10 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Core finding indicates tumor suppressor genes with segmental duplications have increased deletion rates.
Data from TCGA shows significant differences in log2 copy-number between genes with and without segmental duplications.
The study utilized the Illumina HiSeq platform to assess deletion frequencies across various tumor types.
Understanding these patterns enhances insights into genetic instability associated with tumor suppressor genes.

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Analysis reveals higher deletion frequencies in tumor suppressor genes with segmental duplications, suggesting notable structural variations.

Deletion frequency (log2 copy-number) comparison for with SDs versus without SDs TSGs across TCGA dataset (Illumina HiSeq).

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Huang et al. (2025) studied this question.

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