Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759756

Key Points

Tumor suppressor genes with segmental duplications show higher rates of somatic deletions.
Gene size is compared between tumor suppressor genes and oncogenes, highlighting key differences.
Structural variations in genes can lead to significant implications for cancer development.
Understanding these variations helps in assessing genetic risks associated with cancer.

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Implication

Analysis reveals that tumor suppressor genes with segmental duplications are more prone to structural variations, indicating significant genetic risks.

Abstract

Gene size comparisons between with SDs and without SDs genes for TSGs and oncogenes.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0308 https://doi.org/10.1158/0008-5472.29759756

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Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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