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September 29, 2025Open Access

Supplementary Figure 9 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang Lin Zhang Huarong Chen Xiaodong Liu Likai Tan Dan Huang Yingzhi Liu Yushan Wang Xinyi Zhang Alfred S.L. Cheng Maggie Haitian Wang Wei Kang Ka–Fai To Jun Yu Ho Ko Le Yu Sunny H. Wong Tony Gin Matthew T.V. Chan Xiansong Wang William Ka Kei Wu

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Key Points

TSGs with segmental duplications exhibit a higher frequency of structural variations compared to those without.
The analysis includes gene size distributions of 105 TSGs with segmental duplications and 315 size-matched controls.
Genomic assessments reveal that somatic deletions are more prominent in TSGs with segmental duplications.
Results suggest that segmental duplications may contribute to genetic instability in tumor suppressor genes.

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Implication

Analysis shows that tumor suppressor genes with segmental duplications experience more structural variations, implying higher deletion rates.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb167b https://doi.org/10.1158/0008-5472.30235065

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 9 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
2Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
3Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
4Supplementary Figure 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
5Supplementary Figure 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025

Supplementary Figure 10 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
Supplementary Figure 10 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025
Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations2025