Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka–Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.30235071

Key Points

Tumor suppressor genes with segmental duplications are more prone to somatic deletions, indicating a structural instability.
Comparison shows significant differences in gene size between those with segmental duplications and those without.
Increased susceptibility to structural variations in tumor suppressor genes may contribute to cancer progression.
Data highlights the importance of gene structure in understanding the mechanisms of tumorigenesis.

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Implication

Analysis reveals that tumor suppressor genes with segmental duplications show increased somatic deletions, suggesting a vulnerability in their structure.

Abstract

Gene size comparisons between with SDs and without SDs genes for TSGs and oncogenes.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb1666 https://doi.org/10.1158/0008-5472.30235071

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Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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